CBDA (cannabidiolic acid) is one of numerous chemicals generated by cannabis and hemp. It is abundant in the live plants of CBD types and transforms to the more well-known cannabinoid CBD (cannabidiol) over time and when exposed to heat. Today we are going to learn what are the health benefits of CBDA (cannabidiolic acid).
Cannabinoids are cannabis components that interact with human bodies to generate medicinal and recreational effects ranging from pain and stress alleviation to exhilaration. CBD and THC are the most well-known cannabinoids, and both originated from the precursor “mothership” cannabinoid known as CBGA (cannabigerolic acid).
CBGA transforms to three primary cannabinoid precursor chemicals, depending on which plant enzymes are triggered to drive the synthesis:
CBDA is converted to CBD when the cannabis plant is exposed to either heat or sunshine during decarboxylation. In other words, CBDA is the raw form or precursor to CBD.
CBDA is often found as capsules, tinctures, and topicals these days. Many individuals juice raw cannabis to acquire their daily dosage of CBDA.
But what exactly does CBDA accomplish and why is it so important?
CBDA’s Potential Medical Benefits
So, let’s go deeper to our subject. What are the health benefits of CBDA? We will find that there are many.
CBDA, unlike other cannabinoids, does not bind directly to either the CB1 or CB2 receptors. CBDA, on the other hand, works with the endocannabinoid system by blocking the cyclooxygenase-2 (COX-2) enzyme. COX-2 enzymes are linked to inflammation following an injury or illness, hence CBDA can alleviate inflammation and discomfort by suppressing COX-2 enzymes.
CBDA was observed to impact levels of serotonin, a neurotransmitter generated by nerve cells to help in cell signaling, in one mouse investigation. Serotonin is essential for basic human processes such as motor abilities, sleep, feeding, digestion, and emotions.
A variety of stimuli, including as radiation and chemotherapy, cause the body to release excessive serotonin, resulting in nausea and vomiting. While medicine can usually control vomiting, nausea is more difficult to manage. Because nausea is a continual sensation, many cancer patients claim it causes far more suffering than vomiting. In fact, one in every five patients considers terminating cancer therapy in order to avoid nausea.
Scientists have shown that CBDA can impact the body’s 5-HT serotonin-producing receptors, implying that CBDA could be used as a drug to treat chemotherapy-induced nausea and vomiting (CINV) and other illnesses that cause similar symptoms. More research, however, is required.
When we asked you “What are the health benefits of CBDA?”, could you list all the ones we mentioned above?
CBDA Research in the Present
CBDA has been studied by scientists for over a decade.
An early 2008 research investigated CBDA’s potential as an anti-inflammatory drug by focusing on its COX-2 inhibitor properties. The researchers compared CBDA’s molecular structures to those of nonsteroidal anti-inflammatory medicines (NSAIDs), which are routinely used to treat inflammation, and discovered that their chemical structures were very similar; both are known to block COX-2 receptors. CBDA showed promise as a possible anti-inflammatory drug in this preliminary investigation.
CBDA may be a potent anticonvulsant in the same manner as it suppresses nausea. In fact, scientists have discovered that CBDA has 100 times the affinity for 5-HT receptors as CBD; one explanation for this is that CBDA has higher bioavailability, which allows the body to digest the chemical with less effort and in less time.
This similar receptor affinity might imply that CBDA could successfully combat depression. After all, CBDA functions on the 5-HT receptors in the same manner that a selective serotonin reuptake inhibitor (SSRI) antidepressant does.
What are the health benefits of CBDA when it come to new researches? Currently, the majority of CBDA investigations are preclinical non-human studies. So hard to tell precisely. While human studies are required, certain medicinal cannabis businesses, such as GW Pharmaceuticals in the United Kingdom, are paving the way. GW Pharmaceuticals produces Epidiolex, a pharmaceutical-grade CBD oil that was the first cannabis-derived prescription medicine authorized by the US Food and Drug Administration (FDA).
Interestingly, the FDA ordered the business to do not only CBD research, but also CBDA research, and GW’s own study suggests that CBDA is an even more effective seizure therapy. The business has also applied for two other CBDA medical-use patents, one for inflammatory skin conditions and one for cancer therapy.
Although CBDA cancer research has so far only been conducted on isolated cells, preliminary findings suggest that CBDA may inhibit the migration of a particularly aggressive kind of breast cancer cell known as MDA-MB-231.
